Cart
sales@molnova.com
Idelalisib (b)
CAS No. 1146702-54-6
Idelalisib (b)( CAL-101,GS-1101 )
Catalog No. M22532 CAS No. 1146702-54-6
Idelalisib is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 27 | In Stock |
|
| 10MG | 39 | In Stock |
|
| 25MG | 63 | In Stock |
|
| 50MG | 80 | In Stock |
|
| 100MG | 115 | In Stock |
|
| 200MG | 174 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIdelalisib (b)
-
NoteResearch use only, not for human use.
-
Brief DescriptionIdelalisib is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
-
DescriptionIdelalisib is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase and caspase cleavage and an induction of apoptosis.
-
In Vitro——
-
In Vivo——
-
SynonymsCAL-101,GS-1101
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
Recptorp110δ
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1146702-54-6
-
Formula Weight415.42
-
Molecular FormulaC22H18FN7O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC[C@H](Nc1ncnc2nc[nH]c12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Brian J Lannutti, Sarah A Meadows, Sarah E M Herman,et al.CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.Blood. 2011 Jan 13;117(2):591-4.
molnova catalog
related products
-
PI3Kβ and δ inhibito...
A potent, highly selective PI3Kβ/δ inhibitor with IC50 of 7.8/5.3 nM respectively.
-
Acalisib
Acalisib (GS-9820, CAL-120) is a potent, isoform-selective PI3K p110δ with IC50 of 12.7 nM.
-
P110δ-IN-1
ME-401 is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).
